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. 2020 Feb 18;11(2):211. doi: 10.3390/genes11020211

Figure 3.

Figure 3

Inhibition of ACE inhibit DPP-4 level and TGFβ signaling in endothelial cells. (A) Western blot analysis in the ACEi and ACEi+AcSDKP treated HMVECs in presence and absence of TGFβ2. Quantification of DPP-4, TGFβR1, FSP-1, p-smad3 and smad3 respectively by densitometry. Representative blots are shown. The data was normalized by β-actin. N = 3 were analyzed in each group. (B) Western blot analysis in the ARB treated HMVECs in presence and absence of TGFβ2. Quantification of DPP-4, TGFβR1, FSP-1, p-smad3 and smad3 respectively by densitometry. Representative blots are shown. The data was normalized by β-actin. N = 3 were analyzed in each group. Data in the graph are presented as mean ± SEM. One-way Anova Tukey test was performed for calculation of statistical significance.