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. 2020 Mar 13;12:1758835920911229. doi: 10.1177/1758835920911229

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© The Author(s), 2020

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 5. — Dual prognostic values based on stratification of patients with HNSCC with respect to invasion and lymph node involvement, chemotherapy response, and stromal index. (a) Kaplan–Meier cumulative OS of all patients (n = 183; bottom panel: Cox proportional hazard ratio in a multivariate analysis, p < 0.001). (b, c) Cumulative DFS of all patients (n = 183) patients stratified based on depth of invasion (T1 versus T2, bottom panel: Cox proportional hazard ratio in a multivariate analysis, p < 0.0001) and T3 versus T4 (bottom panel: Cox proportional hazard ratio in a multivariate analysis, p < 0.0001). (d) Comparison of Shh (p < 0.001) and Nrf2 (p < 0.001) expression between chemo-responders and nonresponders (Student’s t test). (e) Kaplan–Meier cumulative DFS of patients with HNSCC (bottom panel: Cox proportional hazard ratio in a multivariate analysis, p < 0.001; independent two-tailed Student’s t test).

DFS, disease-free survival; HNSCC, head and neck squamous cell carcinoma; OS, overall survival.