Table I.
Hub genes in phases I–IV.
| Phase | Gene | Regulation | Counts | LogFC | P-value |
|---|---|---|---|---|---|
| Phase I | CDK1 | + | 7 | 1.24 | <0.01 |
| KIF11 | + | 7 | 1.27 | 0.01 | |
| BUB1B | + | 6 | 1.13 | 0.02 | |
| BUB1 | + | 5 | 1.17 | 0.01 | |
| CCNA2 | + | 5 | 1.01 | <0.01 | |
| HLA-DPA1 | + | 5 | 1.49 | 0.03 | |
| CENPE | + | 5 | 1.36 | 0.02 | |
| RHOA | + | 4 | 1.47 | <0.01 | |
| KIF15 | + | 4 | 1.11 | <0.01 | |
| CCNB1 | + | 4 | 1.23 | 0.01 | |
| NDC80 | + | 4 | 1.47 | 0.01 | |
| TTK | + | 4 | 1.14 | <0.01 | |
| STAT1 | – | 4 | −1.47 | 0.03 | |
| CXCL10 | + | 4 | 2.47 | <0.01 | |
| KIF23 | + | 4 | 1.48 | 0.01 | |
| KIF4A | + | 3 | 1.00 | 0.05 | |
| PSMB9 | + | 3 | 1.12 | 0.03 | |
| GNG2 | + | 3 | 1.26 | 0.04 | |
| SPAG5 | + | 2 | 1.15 | 0.01 | |
| TRIP13 | + | 2 | 1.09 | 0.02 | |
| ANLN | + | 2 | 1.19 | 0.02 | |
| CDKN3 | + | 2 | 1.83 | <0.01 | |
| KIF14 | + | 2 | 1.15 | 0.01 | |
| MKI67 | + | 2 | 1.45 | 0.01 | |
| NUSAP1 | + | 2 | 1.22 | 0.02 | |
| NEK2 | + | 2 | 1.30 | 0.01 | |
| NCAPG | + | 2 | 1.18 | <0.01 | |
| DLGAP5 | + | 2 | 1.54 | <0.01 | |
| GBP1 | + | 2 | 1.45 | <0.01 | |
| Phase II | STAT1 | – | 9 | −1.03 | 0.02 |
| CXCL10 | – | 6 | −2.16 | 0.02 | |
| CXCL12 | – | 6 | −1.48 | 0.04 | |
| DCN | – | 6 | −1.37 | 0.01 | |
| CCL2 | – | 5 | −1.54 | 0.01 | |
| KIT | – | 5 | −1.26 | 0.05 | |
| IGF1 | – | 5 | −1.86 | <0.01 | |
| OAS2 | – | 4 | −1.37 | 0.01 | |
| IRF7 | – | 4 | −1.08 | 0.01 | |
| ISG15 | – | 4 | −1.83 | 0.02 | |
| FN1 | – | 4 | −1.34 | 0.04 | |
| HGF | – | 4 | −1.22 | 0.02 | |
| HERC6 | – | 3 | −1.71 | <0.01 | |
| MX2 | – | 3 | −1.86 | 0.01 | |
| IFIT3 | – | 3 | −1.79 | <0.01 | |
| IFIT1 | – | 3 | −2.96 | <0.01 | |
| GBP1 | – | 3 | −1.20 | 0.01 | |
| CDC6 | + | 3 | 1.40 | 0.01 | |
| IFIT5 | – | 2 | −1.11 | <0.01 | |
| IFI6 | – | 2 | −1.55 | 0.01 | |
| SP110 | – | 2 | −1.43 | <0.01 | |
| IFI44 | – | 2 | −1.87 | <0.01 | |
| DDX60 | – | 2 | −1.18 | <0.01 | |
| IFIT2 | – | 2 | −1.67 | <0.01 | |
| RSAD2 | – | 2 | −2.66 | <0.01 | |
| Phase III | BIRC5 | + | 9 | 1.13 | <0.01 |
| TOP2A | + | 8 | 1.36 | <0.01 | |
| KIF2C | + | 6 | 1.04 | <0.01 | |
| MCM10 | + | 6 | 1.16 | 0.01 | |
| VEGFA | + | 6 | 1.27 | <0.01 | |
| MAD2L1 | + | 5 | 1.03 | <0.01 | |
| KIF15 | + | 5 | 1.45 | <0.01 | |
| ASPM | + | 5 | 1.70 | <0.01 | |
| FOXM1 | + | 5 | 1.18 | 0.01 | |
| MX2 | + | 4 | 1.34 | 0.01 | |
| STAT1 | + | 4 | 1.20 | <0.01 | |
| PLXNA4 | – | 4 | −1.15 | 0.01 | |
| AR | – | 4 | −1.69 | <0.01 | |
| CCND1 | – | 3 | 1.20 | <0.01 | |
| OAS2 | + | 3 | 1.05 | <0.01 | |
| ACLY | + | 3 | 1.55 | 0.01 | |
| GNG2 | + | 3 | −1.21 | <0.01 | |
| RSAD2 | + | 2 | 1.85 | <0.01 | |
| ISG15 | + | 2 | 1.82 | <0.01 | |
| IFI35 | + | 2 | 1.35 | 0.01 | |
| IRF5 | + | 2 | 1.46 | <0.01 | |
| SAMHD1 | + | 2 | 1.05 | <0.01 | |
| MKI67 | + | 2 | 1.20 | <0.01 | |
| PLK4 | + | 2 | 1.03 | 0.01 | |
| AHCTF1 | + | 2 | 1.03 | <0.01 | |
| NUDC | + | 2 | 1.07 | <0.01 | |
| EXO1 | + | 2 | 1.29 | <0.01 | |
| PLXNA3 | + | 2 | 1.01 | 0.01 | |
| MMP9 | + | 2 | 2.55 | <0.01 | |
| PLAUR | + | 2 | 1.01 | <0.01 | |
| Phase IV | PIK3CA | + | 9 | 1.42 | <0.01 |
| CXCL8 | + | 8 | 1.28 | 0.05 | |
| ITGB1 | + | 8 | 2.20 | <0.01 | |
| PTK2 | + | 8 | 1.33 | <0.01 | |
| GNG2 | + | 6 | 1.18 | 0.05 | |
| ITGA1 | + | 6 | 1.33 | <0.01 | |
| GNG12 | – | 6 | −1.14 | <0.01 | |
| FOS | – | 5 | −1.13 | 0.05 | |
| EDN1 | + | 5 | 1.07 | <0.01 | |
| NMU | – | 4 | −2.23 | <0.01 | |
| LPAR5 | – | 4 | −1.36 | <0.01 | |
| STAT1 | + | 3 | 1.75 | <0.01 | |
| FN1 | + | 3 | 3.61 | <0.01 | |
| GSTM1 | – | 3 | −1.09 | 0.02 | |
| PLA2G4A | – | 3 | −1.41 | 0.02 | |
| CXCR4 | + | 2 | 1.58 | <0.01 | |
| HCAR3 | – | 2 | −1.60 | <0.01 | |
| S1PR5 | – | 2 | −1.56 | <0.01 | |
| CXCL5 | – | 2 | −2.10 | 0.01 | |
| NQO1 | – | 2 | −1.38 | 0.01 | |
| CXCL11 | + | 2 | 1.69 | 0.02 | |
| COMP | + | 2 | 1.62 | 0.01 | |
| MAPK12 | + | 2 | 1.38 | <0.01 |
+, upregulated; -, downregulated.