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. 2020 Feb 13;8(2):253. doi: 10.3390/microorganisms8020253

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Sensitivity and tolerance to antimicrobial peptides (AMPs). JSG698 used for WT S. Typhi. (A) Growth from input of WT planktonic Salmonella after 2-hour exposure to each AMP at the minimum inhibitory concentration (MIC) determined by CFU enumeration (data are normalized to AMP-free control) (n = 3). S. Typhimurium challenged with 0.49 µg/mL polymyxin B and 10 µg/mL melittin. S. Typhi challenged with 0.24 µg/mL polymyxin B and 10 µg/mL melittin. Significance calculated by two-way ANOVA with Dunnett’s multiple comparison test (***, p <0.0005; ****, p < 0.0001). (B,C) Biofilm tolerance to AMPs supplied at 10× the WT planktonic MIC. Significance was tested for by two-way ANOVA with a Sidak multiple comparison correction (n = 3, daily experiments conducted in triplicate). Error bars indicate SD.

Sensitivity and tolerance to antimicrobial peptides (AMPs). JSG698 used for WT S. Typhi. (A) Growth from input of WT planktonic Salmonella after 2-hour exposure to each AMP at the minimum inhibitory concentration (MIC) determined by CFU enumeration (data are normalized to AMP-free control) (n = 3). S. Typhimurium challenged with 0.49 µg/mL polymyxin B and 10 µg/mL melittin. S. Typhi challenged with 0.24 µg/mL polymyxin B and 10 µg/mL melittin. Significance calculated by two-way ANOVA with Dunnett’s multiple comparison test (***, p <0.0005; ****, p < 0.0001). (B,C) Biofilm tolerance to AMPs supplied at 10× the WT planktonic MIC. Significance was tested for by two-way ANOVA with a Sidak multiple comparison correction (n = 3, daily experiments conducted in triplicate). Error bars indicate SD.