Table 2.
The minimum inhibitory concentrations (MICs) of P-113 and P-113Tri against C. albicans glycosylation mutants.
| MIC90 (μg/mL) a in LYM broth | ||
|---|---|---|
| P-113 | P-113Tri | |
| O-linked Glycosylation Mutants | ||
| CAF2-1 (Control) | 6 | 1.5 |
| SPCa2 (Pmt1) | ND b | ND b |
| SPCa4 (Pmt2) | 6 | 1.5 |
| SPCa6 (Pmt4) | 6 | 3 |
| SPCa8 (Pmt6) | 6 | 3 |
| SPCa10 (Pmt5) | 12 | 3 |
| NGY152 (Control) | 12 | 3 |
| NGY145 (Mnt2) | 24 | 3 |
| NGY158 (Mnt1) | 6 | 1.5 |
| NGY337 (Mnt1Mnt2) | 12 | 6 |
| N-linked glycosylation mutants | ||
| NGY152 (Control) | 12 | 3 |
| NGY516 (Mnt4Mnt5) | 24 | 1.5 |
| NGY1227 (Mnt3Mnt5) | >24 | 1.5 |
| NGY357 (Och1) | >24 | 12 |
| CDH15 (Mnn4) | 24 | >12 |
| O and N-linked glycosylation mutants | ||
| NGY355 (Pmr1) | 3 | 3 |
a The MIC90 was measured after the cells were incubated with each peptide for 48 h. b ND: Not determined.