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. Author manuscript; available in PMC: 2020 Nov 1.
Published in final edited form as: Traffic. 2019 Sep 12;20(11):829–840. doi: 10.1111/tra.12691

Figure 4.

Figure 4.

ATPase mediated mRNP remodeling at the cytoplasmic side of the NPC. (A) Schematic diagram of the interaction network of the mRNA export platform at the cytoplasmic side of the NPC. (B) Schematic of Dbp5/DDX19 mediated dissociation of the export receptor from the mRNP, and regulation of the Dbp5/DDX19 catalytic cycle. (C) Structure of DDX19 bound to ADP (PDB ID 3EWS). (D) Structure of DDX19 bound to an ATP-analogue and poly(U) RNA (PDB ID 3G0H). (E) Structure of the Dbp5•Gle1•IP6 complex in the presence of ADP (PDB ID 3RRN). (F) Structure of the DDX19•GLE1•NUP42 complex in the presence of ADP (PDB ID 6B4I). (G) Structure of the DDX19-NTD•NUP214 complex in the presence of ADP (PDB ID 3FMO). (H) Structure of RAE1 in complex with a NUP98 fragment (PDB ID 3MMY).