Table 3.
Thyroid Nodule Location and the Risk of Thyroid Malignancy Adjusted for Other Variables
| Variables | Univariate analysis |
Multivariate analysis |
||
|---|---|---|---|---|
| Unadjusted model |
Adjusted model |
|||
| OR (95% CI) | p | aOR (95% CI)a | p | |
| Nodule location | ||||
| Isthmus | 2.4 (1.6–3.6) | <0.0001 | 2.4 (1.5–3.9) | 0.0007 |
| Upper | 1.9 (1.4–2.8) | 0.0004 | 1.8 (1.2–2.7) | 0.0055 |
| Middle | 1.3 (0.9–1.7) | 0.0607 | 1.5 (1.1–2.0) | 0.0107 |
| Lower—ref | — | — | — | — |
| Age | 0.98 (0.97–0.99) | <0.0001 | 0.98 (0.97–0.99) | <0.0001 |
| Sex (ref = female) | 1.7 (1.3–2.2) | <0.0001 | 1.8 (1.4–2.5) | <0.0001 |
| Family history (ref = no) | 1.6 (1.2–2.2) | 0.0055 | 1.5 (1.0–2.2) | 0.0409 |
| Radiation exposure (ref = no) | 1.1 (0.8–1.4) | 0.7496 | — | — |
| Maximum size | 0.97 (0.96–0.98) | <0.0001 | 0.97 (0.96–0.98) | 0.6951 |
| TIRADS | ||||
| TR2 | 4.5 (0.8–84.6) | 0.0871 | 4.4 (0.8–82.3) | 0.0953 |
| TR3 | 14.7 (3.2–261.5) | <0.0001 | 13.1 (2.8–233.5) | <0.0001 |
| TR4 | 29.0 (6.4–510.9) | <0.0001 | 25.8 (5.7–455.4) | <0.0001 |
| TR5 | 167.4 (37.3–999.9) | <0.0001 | 155.6 (34.5–999.9) | <0.0001 |
| TR1–ref | — | — | — | — |
a
OR adjusted for age, sex, family history, radiation exposure, maximum size, and ACR-TIRADS.
CI, confidence interval; OR, odds ratio.