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Conceptual basis for redox-based molecular code. OxyR can sense and differentiate among Cys-based modifications, providing the basis for a molecular code for redox signaling. Different redox modifications of OxyR can lead to transcription of unique regulons. The SOH and SNO-dependent regulons have been identified, whereas regulons activated by glutathionylation and thioesterification are hypothetical. SNO, S-nitrosylated; SOH, S-sulfenylation.
