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. 2020 Jan 23;10(2):196. doi: 10.3390/nano10020196

Table 1.

Biomedical applications of nanocellulose/nanocarbon composites.

Application Nanocellulose/Nanocarbon Composites Containing:
Fullerenes Graphene CNTs Nanodiamonds Others
Radical scavenging NH2-CNC/C60 [34]; CNC/C60(OH)30 [92]
Photodynamic cancer therapy TEMPO-oxidized CNC/C60-NH2 [35]
Photothermal, chemo-photothermal therapy Bacteria: [93]
Cancer: [94]
Drug delivery Anticancer drugs (doxorubicin) [72,95,96] Anticancer and other drugs [16] Anticancer drugs (doxorubicin) [97] Carbon quantum dots: Anticancer drugs (temozolomide) [28]
(Bio)sensors Electrochemical: cholesterol [98]; glucose and bacteria [110]; avian leucosis virus [111]; organic liquids [112] Electrochemical:
ATP metabolites [102]; oxygen [84]
Electrochemical: Biotin [66] Carbon black: Electrochemical aptasensor for S. aureus [32]; electrochemical sensor for H2O2 [33]
Piezoelectric: strain, human motion [63,99,113] Piezoresistance and thermoelectric-based: pressure and temperature [103]; pressure [17];
strain, human motion [90,91,114];
humidity, human breath [104]
Carbon black: Strain, human motion [31,33]
Optical:
oxygen and temperature [115]; oxygen [116]
Optical: SERS: bilirubin [100]; Fluorescence: laccase [71] Carbon quantum dots: optical sensor for biothiols [26]
Acoustic: ammonia [101]
Isolation of biomolecules Histidine-rich proteins, hemoglobin [77]; bovine serum albumin [79]
Electrical stimulation of tissues Cardiac tissue [52]; neural tissue [106]
Tissue engineering (TE) General cell biocompatibility [68,69,87]; bone TE [37,59]; neural TE [105]; vascular TE [107] Neural tissue engineering [51]; TE in general [117]
Wound dressing/healing Polysaccharides/fullerene C60 derivatives [118] Human dermal fibroblasts in vitro [108]; mouse model in vivo [109] L929 fibroblasts in vitro [58,62]; HeLa cells in vitro, wound dressings delivering doxorubicin [97] Activated carbon: antibacterial wound dressing [30]