Table 1:

Summary of nPM effects in vivo and in vitro

	In vitro : N2a-APP/swe				In vivo (hAPP/swe)
	1 μg/ml -24h	5 μg/ml -24h	10 μg/ml -24h	nPM+NAC*	150h
Aβ40-42 Aβ plaque load	nc	↑	↑	↓	↑
APP (lipid raft)	nc	↓	↓	↑	↑
NO	↑	↑	↑
MitoSOX	nc	↑	↑
3NT	nc	↑	↑
4-HNE	nc	↑	↑	↓	↑
CTx puncta	↑	↑	↑

“↑” increase, “↓“ decrease, “nc” no change, “blank” data not available,

^*compared to nPM alone; NAC (N-acetyl L-cysteine). We propose a hierarchy of nPM effects, with lower dose inducing increases NO as first effect, but still below the threshold of oxidative stress required for changes in protein levels and increased production of Aβ peptides.