Table 2.
Genotoxicity of Al0 NMs, Al2O3 NMs and AlCl3 in rats treated orally detected by the micronucleus assay in bone marrow.
| Genotoxicity | Myelotoxicity | ||
|---|---|---|---|
| Micronucleated PCE/2 000 PCE | %PCEs | ||
| Doses (mg/kg bw/day) | Mean ± SD | Mean ± SD | |
| Control | 1.3 ± 0.91 | 72.5 ± 26 | |
| Al0 | 6 | 2.0 ± 2.0 | 66.3 ± 13 |
| 12.5 | 1.5 ± 0.8 | 71.5 ± 8 | |
| 25 | 2.1 ± 1.0 | 74.7 ± 16 | |
| Al2O3 | 6 | 1.1 ± 0.7 | 68.4 ± 18 |
| 12.5 | 1.6 ± 1.3 | 65.8 ± 17 | |
| 25 | 0.9 ± 0.8 | 56.7 ± 17 | |
| AlCl3 | 25 | 1.5 ± 0.7 | 65.9 ± 19 |
| MMS | 100, 100, 80 | 16.7 ± 3.7 * | 44.5 ± 12 |
NCE: normochromatic erythrocytes; PCEs: polychromatic erythrocytes; results correspond to mean ± SD, n = 5; * p < 0.001 with the Pearson X2 with Yate’s correction.