Table 3.
Experimental results based on a Minitab full factorial design.
| Run Order | Blocks | A | B | C | Mean Size of FIS-PVP NPs (nm) |
Span (D90–D10)/D50 |
|---|---|---|---|---|---|---|
| 1 | 1 | −1 | −1 | −1 | 71.7 ± 11.9 | 0.43 |
| 2 | 1 | 1 | -1 | −1 | 83.3 ± 19.3 | 0.54 |
| 3 | 1 | −1 | 1 | −1 | 297.9 ± 72.87 | 0.61 |
| 4 | 1 | 1 | 1 | −1 | 328.1 ± 79.6 | 0.63 |
| 5 | 1 | −1 | −1 | 1 | 78.1 ± 18.5 | 0.62 |
| 6 | 1 | 1 | −1 | 1 | 75.2 ± 15.9 | 0.56 |
| 7 | 1 | −1 | 1 | 1 | 309.0 ± 72.9 | 0.58 |
| 8 | 1 | 1 | 1 | 1 | 357.4 ± 70.1 | 0.51 |
| 9 | 1 | 0 | 0 | 0 | 309.7 ± 54.4 | 0.43 |
| 10 | 1 | 0 | 0 | 0 | 300.0 ± 56.9 | 0.45 |
| 11 | 1 | 0 | 0 | 0 | 297.6 ± 53.7 | 0.48 |
Note: A—solvent/antisolvent (EtOH/DCM, v/v), B—FIS/PVP mass ratio (w/w), and C—solution flow rate (ml min−1) following the corresponding levels represented in Table 2.