Table 3.

Univariate and Multivariable Analyses of DFS

Variables	Univariate			Multivariate
	HR	95% CI	p	HR	95% CI	p
Age (≥60 years vs <60 years)	0.792	0.493–1.273	0.336
Gender (male vs female)	1.144	0.676–1.935	0.617
Tumor location (upper/middle vs down)	1.130	0.691–1.849	0.625
Tumor size (≥5cm vs <5 cm)	1.174	0.724–1.902	0.516
Differentiation (poor vs well/moderate)	1.734	1.065–2.824	0.027	1.428	1.087–2.344	0.038
Lymph node metastasis (positive vs negative)	2.081	1.257–3.446	0.004	1.564	0.932–2.627	0.091
Vascular invasion (yes vs no)	1.689	1.041–2.740	0.034	1.212	0.733–2.004	0.454
TNM stage (III vs I/II)	2.103	1.241–3.563	0.006	1.742	1.016–2.987	0.044
HOXD9 expression (high vs low)	2.545	1.574–4.115	<0.001	2.120	1.284–3.502	0.003

Abbreviations: DFS, disease-free survival; HR, hazard ratio; Cl, confidence interval; TNM, tumor node metastasis; HOXD9, homeobox D9.