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. 2020 Apr;26(4):512–528. doi: 10.1261/rna.070490.119

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© 2020 Thulson et al.; Published by Cold Spring Harbor Laboratory Press for the RNA Society

This article is distributed exclusively by the RNA Society for the first 12 months after the full-issue publication date (see http://rnajournal.cshlp.org/site/misc/terms.xhtml). After 12 months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.

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FIGURE 1. — HTLV-1 programmed ribosomal frameshift sites. (A) A simplified cartoon of the HTLV-1 RNA genome is shown. −1 PRF sites (starred) are used for the translation of the pro and pol open reading frames, which are in the −1 and −2 reading frames relative to gag, respectively. (B) The HTLV-1 pro-pol frameshift site includes a slippery sequence (underlined), a spacer (nucleotides 2246–2251), and a downstream structure, which was proposed to be an H-type pseudoknot. The nucleotide numbering is derived from the NCBI reference sequence NC_001436.1.