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. 2020 Apr;26(4):454–469. doi: 10.1261/rna.072728.119

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© 2020 Costa Cruz et al.; Published by Cold Spring Harbor Laboratory Press for the RNA Society

This article is distributed exclusively by the RNA Society for the first 12 months after the full-issue publication date (see http://rnajournal.cshlp.org/site/misc/terms.xhtml). After 12 months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.

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FIGURE 6. — Cases that require nonpreferred ADAR for efficient RNA editing. (A–C) Editing ratios of five sites in the serotonin 5-HT_2CR (A), CACNA1D isoleucine/methionine (I/M) (B), and FLNB glutamine/arginine (Q/R) (C) sites in the indicated tissues isolated from wild-type (WT), Adar1^E861A/E861AIfih^−/− mice (Adar1 knock-in [KI]), and Adar2^−/−Gria2^R/R (Adar2 knockout [KO]) mice are shown. Editing ratios are displayed as the mean ± SEM (n = 3 mice for each group; Student's t-test, [*] P < 0.05, [**] P < 0.01, [***] P < 0.001, n.s., not significant). The editing ratio of each mouse is also displayed as a circle on the right side of each column.