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. 2020 Apr;26(4):454–469. doi: 10.1261/rna.072728.119

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© 2020 Costa Cruz et al.; Published by Cold Spring Harbor Laboratory Press for the RNA Society

This article is distributed exclusively by the RNA Society for the first 12 months after the full-issue publication date (see http://rnajournal.cshlp.org/site/misc/terms.xhtml). After 12 months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.

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FIGURE 7. — Comparison of the combined editing pattern in the same transcripts among Adar mutant mice. (A–C) The frequency of each combined editing pattern of the five sites (A, B, E, C, and D in order) in the serotonin 5-HT_2CR (A), the two sites (isoleucine/methionine [I/M] and tyrosine/cysteine [Y/C] in order) in CACNA1D (B), and the three sites (Y/C, glutamine/arginine [Q/R] and lysine/arginine [K/R] in order) in BLCAP (C), in the indicated tissues isolated from wild-type (WT; n = 3 mice), Adar1^E861A/E861AIfih^−/− mice (Adar1 knock-in [KI]; n = 3 mice), Adar2^−/−Gria2^R/R (Adar2 knockout [KO]; n = 3 mice), and Adar1 KI Adar2 KO (n = 2 mice) mice is displayed as a percentage.