1. Additional information on included studies.
| Trial | Clear inclusion & exclusion criteria | Sample size (arms) | A priori calculation | Grade 1 ulcer excluded | Intervention well documented |
| Andersen 1982 | Yes | 482 (3) | Yes | Yes | No |
| Aronovitch 1999 | Yes | 217 (2) | No | Yes | Yes |
| Bennett 1998 | Yes | 98 (2) | No | Yes | No |
| Brienza 2010 | Yes | 113/119 (2) | No | No | Yes |
| Cadue 2008 | Yes | 70/69 (2) | No | No | Yes |
| Cavicchioli 2007 | Yes | 170 (2) | No | No | Yes |
| Cobb 1997 | Yes | 123 (2) | No | No | Yes |
| Collier 1996 | No | 99 (9) | No | Not applicable | Yes |
| Conine 1990 | Yes | 187 (2) | No | Yes | No |
| Conine 1993 | Yes | 288 (2) | No | Yes | Yes |
| Conine 1994 | Yes | 163 (2) | No | Yes | Yes |
| Cooper 1998 | Yes | 100 (2) | No | Yes | Yes |
| Daechsel 1985 | Yes | 32 (2) | No | No | Yes |
| Demarre 2011 | Yes | 298/312 (2) | No | No | Yes |
| Donnelly 2011 | Yes | 120/119 (2) | No | No | Yes |
| Economides 1995 | Yes | 12 (2) | No | Yes | Yes |
| Ewing 1964 | No | 30 (2) | No | No | Yes |
| Exton‐Smith 1982 | Yes | 66 (2) | No | Yes | Yes |
| Feuchtinger 2006 | Yes | 175 (2) | Yes | No | Yes |
| Gebhardt 1996 | Yes | 43 (2) | No | Unclear | Yes |
| Gentilello 1988 | Yes | 65 (2) | No | No | Yes |
| Geyer 2001 | Yes | 32 (2) | No | Unclear | Yes |
| Gilcreast 2005 | Yes | 338 (2) | Yes | No | Yes |
| Goldstone 1982 | Yes | 75 (2) | No | No | Yes |
| Gray 1998 | Yes | 100 (2) | No | Yes | No |
| Gray 1994 | Yes | 170 (2) | No | Yes | Yes |
| Gunningberg 2000 | Yes | 101 (2) | Yes | Yes | Yes |
| Hampton 1997 | Yes | 75 (2) | No | No | Yes |
| Hofman 1994 | Yes | 44 (2) | Yes | Yes | Yes |
| Inman 1993 | Yes | 100 (2) | Yes | Yes | No |
| Jolley 2004 | Yes | 539 (2) | No | No | Yes |
| Kemp 1993 | Yes | 84 (2) | No | No | No |
| Keogh 2001 | Yes | 100 (2) | Yes | Yes | Yes |
| Laurent 1998 | Yes | 312 (4) | Yes | Yes | Yes |
| Lazzara 1991 | Yes | 74 (2) | No | Yes | No |
| Lim 1988 | Yes | 62 (2) | No | Yes | Yes |
| McGowan 2000 | Yes | 297 (2) | Yes | No | Yes |
| Mistiaen 2009 | Yes | 5434 (2) | Yes | No | Yes |
| Nixon 1998 | Yes | 446 (2) | Yes | Yes | Yes |
| Nixon 2006 | Yes | 1972 (2) | Yes | Yes | Yes |
| Price 1999 | Yes | 80 (2) | Yes | Yes | No |
| Ricci 2013 | Yes | 25 (2) | No | Yes | Yes |
| Russell 2000 | Yes | 198 (2) | No | No | Yes |
| Russell 2003 | Yes | 1166 (2) | Yes | No | Yes |
| Sanada 2003 | Yes | 103 (3) | Unclear | No | Yes |
| Santy 1994 | Yes | 505 (5) | Yes | No | Yes |
| Schultz 1999 | Yes | 413 (2) | Yes | No | No |
| Sideranko 1992 | Yes | 57 (3) | No | No | No |
| Stapleton 1986 | Yes | 100 (3) | No | Yes | No |
| Summer 1989 | Yes | 83 (2) | No | No | Yes |
| Takala 1996 | Yes | 40 (2) | Yes | Yes | Yes |
| Taylor 1999 | Yes | 44 (2) | Yes | No | Yes |
| Theaker 2005 | Yes | 62 (2) | Yes | Unclear | Yes |
| Tymec 1997 | Yes | 52 (2) | Yes | Yes | Yes |
| van Leen 2011 | No | 41/42 (2) | No | Yes | No |
| Vanderwee 2005 | Yes | 447 (2) | Yes | Yes | Yes |
| Vermette 2012 | No | 55 (2) | Yes | Unclear | Yes |
| Vyhlidal 1997 | Yes | 40 (2) | No | Yes | Yes |
| Whitney 1984 | No | 51 (2) | No | No | No |