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. Author manuscript; available in PMC: 2020 Mar 16.
Published in final edited form as: J Am Chem Soc. 2019 Jan 15;141(4):1435–1440. doi: 10.1021/jacs.8b11465

Figure 5.

Figure 5.

Synthesis of helical pyrazoles 12a–22a. * Isomer ratio was measured by 1H NMR of the crude mixture. n.i. = not isolated. a See Supporting Information for detailed conditions.