Table 1.
Characteristic | Participants, No. (%)b |
---|---|
Male sex | 60 (100) |
Age, median (IQR), y | 34 (28–41) |
Interval median (IQR), d | |
From confirmed HIV-positive test to ART initiation | 29 (14–47) |
From estimated date of seroconversion to ART initiation | 49 (32–93) |
From ART initiation to first VL <50 copies/mLc | 133 (90–230) |
Baseline values, median (IQR) | |
CD4 T-cell count, cells/μLd | 530 (409–663) |
CD8 T-cell count, cells/μLd | 1037 (837–1318) |
CD4/CD8 ratiod | 0.5 (0.4–0.8) |
VL, log10 copies HIV RNA/mL | 5.4 (4.5–6.4) |
Method for diagnosing primary HIV infection | |
Antigen positive (p24 or PCR) but antibody negative | 25 (42) |
Rising antibody titer | 1 (2) |
Negative test result within 6 mo of positive result | 28 (47) |
Recent incidence testing algorithm | 6 (10) |
Mode of acquisition | |
MSM | 54 (90) |
MSW | 1 (2) |
Unknown/unrecorded | 5 (8) |
Initial ART regimen | |
Unknown/unrecorded | 3 (5) |
Backbone | |
Tenofovir containing | 52 (87) |
Abacavir containing | 5 (8) |
Additional agent(s) | |
Protease inhibitor | 33 (55) |
NNRTI | 11 (18) |
Integrase inhibitor | 12 (20) |
Protease inhibitor plus integrase inhibitor | 1 (2) |
Abbreviations: ART, antiretroviral therapy; HIV, human immunodeficiency virus; MSM, men who have sex with men; MSW, men who have sex with women, NNRTI, nonnucleoside reverse-transcriptase inhibitor; PCR, polymerase chain reaction; VL, viral load.
aDemographic and baseline clinical characteristics of included participants from the HEATHER cohort.
bData represent no. (%) of participants unless otherwise identified as median (IQR) values.
cFifty-nine of 60 individuals were virologically suppressed to <50 copies/mL before 1-year study visit; the remaining individual achieved virological suppression shortly thereafter, at the next VL measurement (Supplementary Figure 1)
dData available for 59 of 60 individuals.