Table 2.
Proportion (%) Positive Vaccine Take by Lewis and Secretor Status
| Positive Vaccine Take | Positive for Serum IgA and/or SNA Response | Positive for Serum IgA Response | Positive for SNA Response | Positive for RV3-BB Virus Excretion | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Phenotypea | Participants, Proportion (%) | RR (95% CI) | P | Participants, Proportion (%) | RR (95% CI) | P | Participants, Proportion (%) | RR (95% CI) | P | Participants, Proportion (%) | RR (95% CI) | P | Participants, Proportion (%) | RR (95% CI) | P |
| Secretor phenotype (n = 46) | |||||||||||||||
| Secretor | 29/32 (91) | Reference | 21/32 (66) | Reference | 21/32 (66) | Reference | 4/31 (13) | Reference | 23/32 (72) | Reference | |||||
| Nonsecretor | 13/13 (100) | 0.91 (.81–1.01) | .25 | 11/13 (85) | 0.76 (.55–1.09) | .20 | 11/13 (85) | 0.78 (.55–1.09) | .20 | 3/11 (27) | 0.47 (.13–1.79) | .27 | 10/13 (77) | 0.93 (.65–1.35) | .73 |
| Weak secretor | 1/1 (100) | … | 1/1 (100) | … | 1/1 (100) | … | 0/1 (0) | … | 1/1 (100) | … | |||||
| Lewis phenotype (n = 43) | |||||||||||||||
| Positive | 37/40 (93) | Reference | 29/40 (73) | … | 29/40 (73) | … | 7/38 (18) | … | 28/40 (70) | … | |||||
| Negative | 3/3 (100) | 0.93 (.85–1.01) | .62 | 1/3 (33) | … | 1/3 (33) | … | 0/3 (0) | … | 3/3 (100) | … | ||||
| Combined phenotype (n = 43) | |||||||||||||||
| Le, Se (Lewis positive, secretor) | 25/28 (89) | Reference | 19/28 (68) | Reference | 19/28 (68) | Reference | 4/27 (15)j | Reference | 19/28 (68) | Reference | |||||
| Le, se (Lewis positive, nonsecretor) | 12/12 (100) | 0.89 (.79–1.01) | .24 | 10/12 (83) | 0.81 (.57–1.17) | .32 | 10/12 (83) | 0.81 (.57–1.17) | .32 | 3/11 (27)j | 0.54 (.15–2.04) | .37 | 9/12 (75) | 0.91 (.60–1.37) | .65 |
| le, Se (Lewis negative, secretor) | 2/2 (100) | … | 0/2 (0) | … | 0/2 (0) | … | 0/2 (0) | … | 2/2 (100) | … | |||||
| le, sew (Lewis negative, weak secretor) | 1/1 (100) | … | 1/1 (100) | … | 1/1 (100) | … | 0/1 (0) | … | 1/1 (100) | … | |||||
| le, se (Lewis negative, nonsecretor) | 0 | … | 0 | … | 0 | … | 0 | … | 0 | … | |||||
Phenotypes were inferred from genotype type data. See Methods for descriptions of secretor and Lewis phenotypes.
Abbreviations: CI, confidence interval; IgA, immunoglobulin A; le, nonfunctional FUT3; Le, at least 1 functional gene encoding FUT3; RR, relative risk; se, nonfunctional FUT2; Se, at least 1 functional gene encoding FUT2; SNA, serum neutralizing antibody.