Table 2:
Pain Intensity at 24-Month Follow-Up, SENZA-RCT Study
| 10-kHz High-Frequency SCS | Conventional SCS | Difference | |
|---|---|---|---|
| Back Pain Intensity | |||
| VAS point decrease, mean ± SD | 5.0 ± 2.5 cm (66.9% ± 31.8%) |
3.2 ± 3.0 cm (41% ± 36.8%) |
— |
| Responder ratea | 76.5% | 49.3% | 27.2% (95% CI 10.1%–41.8%; P < .001) |
| Remitter rateb | 65.9% | 31% | 34.9% (95% CI 18.0%–49.0%; P NR) |
| Leg Pain Intensity | |||
| VAS point decrease, mean ± SD | 4.7 ± 2.8 cm (65.1% ± 36.0%) |
3.7 ± 3.0 cm (46.0% ± 40.4%) |
— |
| Responder ratea | 72.9% | 49.3% | 23.6% (95% CI; 5.9%–38.6%; P < .001) |
| Remitter rateb | 65.9% | 39.4% | 26.5% (95% CI; 8.0%–41.2%; P < .001) |
Abbreviations: CI, confidence interval; SCS, spinal cord stimulation; SD, standard deviation; VAS, visual analogue scale.
a
Responder: patient with a pain intensity VAS pain score decrease of ≥50% over baseline.
b
Remitter: pain intensity VAS pain score of ≤ 2.5.
Source: Kapural et al, 2016.31