Table A1:

Risk of Bias^a Among Randomized Trials (Cochrane Risk of Bias Tool)

Author, Year	Random Sequence Generation	Allocation Concealment	Blinding of Participants and Personnel	Incomplete Outcome Data	Selective Reporting	Other Bias
Amirdelfan et al, 201832	Low risk	Low risk	Moderate riskb	Low risk	Low risk	—
Bocci et al, 201836	Low risk	Low risk	Moderate riskb	Low risk	Low risk	—
Bolash et al, 201928	Low risk	Low risk	Moderate riskb	Low risk	Low risk	—
De Andres et al, 201729	Low risk	Low risk	Moderate riskb	Low risk	Low risk	—
Kapural et al, 2015, 201630,31	Low risk	Low risk	Moderate riskb	Low risk	Low risk	—
Thomson et al, 201838	Low risk	Low risk	Moderate riskb	Low risk	Low risk	—

^aPossible risk of bias levels: low, high, and unclear.

^bPatients and investigators were not blinded; this may have posed a risk of bias to the main study outcome.