Table A11:

Assessment of the Limitations of Studies Evaluating the Cost-Effectiveness of 10-kHz High-Frequency SCS

Author, Year, Country of Publication	Does the model structure adequately reflect the nature of the health condition under evaluation?	Is the time horizon sufficiently long to reflect all important differences in costs and outcomes?	Are all important and relevant health outcomes included?	Are the clinical inputsa obtained from the best available sources?	Do the clinical inputsa match the estimates contained in the clinical sources?	Are all important and relevant (direct) costs included in the analysis?	Are the estimates of resource use obtained from the best available sources?	Are the unit costs of resources obtained from the best available sources?	Is an appropriate incremental analysis presented, or can it be calculated from the reported data?	Are all important and uncertain parameters subjected to appropriate sensitivity analysis?	Is there a potential conflict of interest?	Overall Judgmentb
NICE, 201769 United Kingdom	Partially	Yes	Yes	Yes	Yes	Partially	Yes	Yes	No	Yes	No	Potentially serious limitations
Annemans, 201459 United Kingdom	Partially	Yes	Yes	No	Yes	Partially	Yes	Yes	Yes	Yes	Unclear	Potentially serious limitations

Abbreviation: NICE, National Institute for Health and Care Excellence.

Note: Response options for all items were “yes,” “partially,” “no,” “unclear,” and “NA” (not applicable).

^aClinical inputs include relative treatment effects, natural history, and utilities.

^bOverall judgment may be “minor limitations,” “potentially serious limitations,” or very serious limitations.“