Figure 4.

Regions with increased connectivity associated with local β-amyloid, local tau, and Apolipoprotein E ε4 allele (APOE4) carrier status. (A) Axial, coronal, and sagittal slices and a 3D view of the biological parametric mapping (BPM) T-map (p < 0.05, extent threshold = 100) illustrating regions with associations between local β-amyloid, increased functional connectivity, moderated by APOE4 carrier status (blue). (B) Axial, coronal, and sagittal slices and a 3D view of the BPM T-map (p < 0.05, extent threshold = 100) illustrating regions that showed associations between local tau, increased connectivity, moderated by APOE4 carrier status (green).