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. 2020 Mar 9;10:208. doi: 10.3389/fonc.2020.00208

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Copyright © 2020 Du, Hou, Mi, Ji, Ma, Ba, Hu, Xie and Chen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Differential clinicopathological features and overall survival (OS) of GBM in the RM1/2 subgroups. (A) Consensus clustering cumulative distribution function (CDF) for k = 2–10. (B) Relative change in area under CDF curve for k = 2–10. (C) Consensus clustering matrix for k = 2. (D) Principal component analysis of the total mRNA expression profile in the TCGA dataset. GBM patients in the RM1 subgroup are marked with red, GBM patients in RM2 are marked with green. (E) Kaplan–Meier OS curves for different subgroups. (F) Heatmap and clinicopathologic features of the two clusters (RM1/2) defined by the m6A RNA methylation regulators consensus expression.