Table 4.

ATF by Age and Drug Class Category

		All Patients	Beta-lactam	Macrolide	Fluoroquinolone	Tetracycline
Age Group	Index Failure Type	n = 199 190	n = 12 516	n = 93 770	n = 82 144	n = 10 760
18–64 y	Composite treatment failure, %	21.2	25.6	21.1	20.5	21.8
	Treatment failure type,a %
	Refill index antibiotic	20.1	11.1	19.6	24.0	8.2
	Change to new antibiotic prescription	72.1	81.9	74.6	65.7	84.2
	CAP hospitalization	4.1	4.4	2.5	6.0	3.4
	CAP ER visit	3.2	2.5	2.8	3.9	3.7
Age Group	Index Failure Type	All Patients	Beta-lactam	Macrolide	Fluoroquinolone	Tetracycline
		n = 52 757	n = 4010	n = 18 284	n = 27 035	n = 3428
≥65 y	Composite treatment failure, %	25.7	27.1	26.6	24.9	26.0
	Treatment failure type,b %
	Refill index antibiotic	22.3	18.9	21.1	24.8	15.2
	Change to new antibiotic prescription	64	70.3	68.9	58.4	71.8
	CAP hospitalization	9.5	7.6	6.4	12.2	9.6
	CAP ER visitd	3.5	2.9	3.0	4.1	2.7

All treatment failure analyses excluded patients with index drug (ceftriaxone and ciprofloxacin), due to low sample numbers.

Abbreviations: ATF, antibiotic treatment failure; CAP, community-acquired pneumonia; ER, emergency room.

^aA total of 404 patients (0.5%) had treatment failures, defined by having both a refill and a fill for a new agent on the same day.

^bA total of 216 patients (0.5%) with treatment failures were defined by having both a refill and a fill for a new agent on the same day.

^cA total of 82 patients (0.6%) with treatment failures were defined by having both a refill and a fill for a new agent on the same day.

^dAll comparisons were statistically significant with a P value <.0001, except for CAP ER visit among the population aged ≥65 years (P = .0036).

^eAdjusted failure rates.