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. Author manuscript; available in PMC: 2020 Jul 1.
Published in final edited form as: J Steroid Biochem Mol Biol. 2019 Apr 5;191:105350. doi: 10.1016/j.jsbmb.2019.03.027

Figure 5.

Figure 5.

A. Observed and extrapolated fractional contribution (ft) of individual efflux transporters to the clearance of TG, AG, EtioG, and DHTG in membrane vesicles, and in human tissues after integrating the scaling factor. The individual scaling factors were derived from the relative abundance of efflux transporters in human liver, intestine and kidney versus in vesicles as shown in Supplemental Table 5. B. A proposed disposition model of glucuronide metabolites of testosterone (T) in liver, intestine and kidney. MRP3 is expressed in basolateral or sinusoidal side, whereas MRP2, MDR1 and BCRP are expressed in apical or canalicular side. MRP3 and MRP2 are more important in the transport of testosterone glucuronides in human liver, intestine and kidney.