Fig 1. Alterations in the expression levels of cardiac cathepsins and their substrates with age.

Relative expression levels of cardiac cathepsin B (CTSB, a), cathepsin D (CTSD, b), cathepsin L (CTSL, c), p62 (d), ATP synthase subunit c (ATPSC, e), and α-synuclein (ASNC, f) in cases of noncardiac death are shown with representative images of immunoblots. n = 27 in each graph. The uncropped images of the immunoblots are presented in S1–S6 Figs.