Table 1. Murine experimental study designs.
| Studya | Vaccine | Toxoid | ||
|---|---|---|---|---|
| Antigen (μg) | Dose (μg) | Antigen (μg) | Dose (μg) | |
| 1 | dscCfaE-CTA2/CTB | 65 | - | - |
| dscCfaE | 25 | CTB | 36.5 | |
| - | - | CTB | 36.5 | |
| dscCfaE | 25 | - | - | |
| - (PBS) | - | - | - | |
| 2 | dscCfaE-CTA2/CTB | 65 | - | - |
| dscCfaE-CTA2/CTB | 21.3b | - | - | |
| dscCfaE-CTA2/CTB | 7.1b | - | - | |
| dscCfaE-CTA2/CTB | 2.4b | - | - | |
| - | - | CTB | 13 | |
| dscCfaE | 25 | - | - | |
| - (PBS) | - | - | - | |
| 3 | dscCfaE-CTA2/CTB | 162 | - | - |
| dscCfaE | 62 | CTB | 91 | |
| dscCfaE | 62 | - | - | |
| - (PBS) | - | - | - | |
a Animals immunized by the IN route for Studies 1 and 2 and by the OG route for study 3.
b For ease of reference in the manuscript, these doses were rounded to the nearest μg to 21, 7 and 2 respectively.