Fig 8. Most of the identified regulon clusters with TCS07 in the genome in other species of Streptococci.

The genomic distance from the response regulator (rr07) to each gene of the regulon was determined in strains with a TCS07 homolog. For genes in operons, only the distance to the first gene was used, and each dot represents a gene homolog. The regulon is spread out in the genome of S. pneumoniae, whereas it mostly clusters around the TCS07 in other species. Except for strH, all genes cluster to TCS07 in at least two of the species. SPD_0156, a hypothetical protein, is part of the TCS07 operon in many species and otherwise absent. gh29 is absent in three of the species. In two of them, endoD has replaced it genomic location, while it is absent in the last.