. 2020 Mar 4;16(3):e1008241. doi: 10.1371/journal.pgen.1008241

Table 3. Linear combinations tested with M₃ compared to hypotheses tested using other GWAS models (M₁ and M₂).

	Type	$Δ_{D D}^{m}$ ^a	$Δ_{D A}^{m}$ ^b	$Δ_{F A}^{m}$ ^c	$Δ_{F F}^{m}$ ^d	M₁	M₂
$Δ_{D D}^{m}$	simple	+1	0	0	0	✔	✔
$Δ_{D A}^{m}$	simple	0	+1	0	0	-	-
$Δ_{F A}^{m}$	simple	0	0	+1	0	-	-
$Δ_{F F}^{m}$	simple	0	0	0	+1	✔	✔
$Δ_{D D + F F}^{m}$	general	+1	0	0	+1	-	✔
$Δ_{D D + D A}^{m}$	general	+1	+1	0	0	-	-
$Δ_{F F + F A}^{m}$	general	0	0	+1	+1	-	-
$Δ_{D A + F A}^{m}$	general	0	+1	+1	0	-	-
$Δ_{D D + D A + F A + F F}^{m}$	general	+1	+1	+1	+1	-	-
$Δ_{D D - F F}^{m}$	divergent	+1	0	0	-1	-	✔
$Δ_{D D - D A}^{m}$	divergent	+1	-1	0	0	-	-
$Δ_{F F - F A}^{m}$	divergent	0	0	-1	+1	-	-
$Δ_{D A - F A}^{m}$	divergent	0	+1	-1	0	-	-
$Δ_{(D D + D A) - (F F + F A)}^{m}$	divergent	+1	+1	-1	-1	-	-
$Δ_{(D D + F F) - (D A + F A)}^{m}$	divergent	+1	-1	-1	+1	-	-
$Δ_{(D D - D A) - (F F - F A)}^{m}$	divergent	+1	-1	+1	-1	-	-

^a $Δ_{D D}^{m} = β_{1 D D}^{m} - β_{0 D D}^{m}$

^b $Δ_{D A}^{m} = β_{1 D A}^{m} - β_{0 D A}^{m}$

^c $Δ_{F A}^{m} = β_{1 F A}^{m} - β_{0 F A}^{m}$

^d $Δ_{F F}^{m} = β_{1 F F}^{m} - β_{0 F F}^{m}$

✔: hypothesis also tested using the corresponding GWAS model

- : hypothesis not tested using the corresponding GWAS model

Table 3. Linear combinations tested with M3 compared to hypotheses tested using other GWAS models (M1 and M2).