Table 3. Pharmacokinetic Parameters of P21S10, P21S8, and HR2P-M2 in Rats Following a Single Dose iv Administration Calculated by Noncompartmental Analysis by Using DAS, version 3.2.8a.
| compd | AUC (0–t) (μg/(mL·h)) | MRT (0–t) (h) | t1/2 (h) | CL ((L/h)/kg) | Cmax (μg/mL) | Vd (L/kg) |
|---|---|---|---|---|---|---|
| P21S10 | 91.3 ± 9.8 | 1.08 ± 0.04 | 1.15 ± 0.15 | 0.041 ± 0.006 | 98.7 ± 6.5 | 0.066 ± 0.004 |
| P21S8 | 44.1 ± 1.0 | 1.03 ± 0.04 | 1.32 ± 0.49 | 0.082 ± 0.004 | 61.8 ± 13.6 | 0.156 ± 0.052 |
| HR2P-M2 | 3.35 ± 0.5 | 1.34 ± 0.14 | 1.54 ± 0.73 | 1.04 ± 0.26 | 17.0 ± 1.3 | 2.188 ± 0.603 |
a
MRT, mean residence time; CL, clearance; Cmax, maximum drug concentration; Vd, volume of distribution.