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. 2016 Feb 15;59(14):6595–6628. doi: 10.1021/acs.jmedchem.5b01461

Table 2. Predicted Cleavage Sites by SARS-CoV 3CLpro.

P4P3P2P1–P1′P2′P3P4′ proteinsa
AVLQ-SGFR TM2/3CLpro
VTFQ-GKFK 3CLpro/TM3
ATVQ-SKMS TM3/?
ATLQ-AIAS ?
VKLQ-NNEL ?
VRLQ-AGNA ?/GFL
PLMQ-SADA GFL/?
TVLG-AVGA ?/RdRp
ATLQ-AENV RdRp/NTPase, etc.
TRLQ-SLEN NTPase, etc./exonuclease
PKLQ-ASQA exonuclease/2′-O-MT
a

TM, Transmembrane; GFL, growth factor-like domain; RdRp, RNA-dependent RNA polymerase; 2′-O-MT, 2′-O-methyltransferase.