Table 6. Inhibitory Activity of Halomethyl Ketonesa.
compd | R | X | IC50 (μM) |
---|---|---|---|
61 | see above structure | see above structure | 10 |
62 | Bn | Cbz-Leu | 15 |
63 | Bn | Cbz-Phe | 20 |
64 | Me | Boc-Leu | 40 |
65 | H | Boc-γ-Glu(OtBu)-Ala | 40 |
66 | H | γ-Glu-Ala | 50 |
67 | Bn | CH3(CH2)8CO-Leu | 50 |
68 | Bn | CH3(CH2)7CO-Leu | >50 |
IC50, half-maximal inhibitory concentration; Bn, benzyl; Me, methyl.