Figure 5.

Evaluation of PeptoBrush 1 as a primary targeting agent for pretargeted imaging. Conventional imaging. (A) Representative SPECT/CT images (maximum intensity projection) at 2, 22, and 72 h after injection of [¹¹¹In]21 in CT26 tumor-bearing mice. Each image is scaled between its minimum and maximum pixel intensity. (B) Image derived mean uptake values (%ID/g) in tissues (n = 4). Pretargeted imaging. (C) Representative SPECT/CT images (maximum intensity projection) at 2 and 22 h p.i. of [¹¹¹In]20 in CT26 tumor-bearing mice pretreated with PeptoBrush 1. (D) Image derived mean uptake values (%ID/g) in tissues (n = 4). Comparison. (E) Tumor-to-muscle (T/M) ratios from conventional and pretargeted SPECT imaging. (F) Tumor-to-blood (T/B) ratios from conventional and pretargeted SPECT imaging. Data are shown as mean and standard error of mean (SEM). Abbreviations: H = heart, L = liver, K = kidney, B = bladder, and T = tumor.