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. 2019 Dec 10;14(1):568–584. doi: 10.1021/acsnano.9b06905

Scheme 1. Synthesis of PeptoBrushes 1–3 by Nucleophilic Ring-Opening Polymerization and Sequential Attachment of TCO Moieties and pSar Side Chains onto the pGlu Backbone.

Scheme 1

Conditions: (A) Synthesis of pGlu backbone. (B) Functionalization of the pGlu backbone with TCO moieties and pSar side chains. Inset: Sketch of the core–shell structure of PeptoBrushes 1–3. The TCO moieties are bound to a polymer and located within hydrophobic TCO patches (yellow), which attract lipophilic Tz derivatives; n = 100, k = pSar grafting density, m = TCO loading (see Table 1).