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. Author manuscript; available in PMC: 2020 Mar 16.
Published in final edited form as: Curr Biol. 2019 Nov 18;29(22):R1179–R1181. doi: 10.1016/j.cub.2019.10.003

Figure 1. RhoA regulates axonal initiation and rate of axonal growth.

Figure 1.

(A) In wild type neurons, a myosin II-mediated actin arc restricts microtubule protrusion into the central growth cone domain, and in turn restrains axonal growth. (B) Neurons in which the RhoA gene is deleted display early axon initiation and rapid axonal growth. Growth cones of RhoA knockout neurons exhibit dismantling of the actin arc, thus allowing accelerated microtubule protrusion into the central growth cone domain.