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. Author manuscript; available in PMC: 2021 Feb 13.
Published in final edited form as: J Med Chem. 2020 Jan 24;63(3):1142–1155. doi: 10.1021/acs.jmedchem.9b01404

Figure 4. The indole N–H of tryptamine derivatives is not necessary to promote dendritogenesis.

Figure 4.

(A) Representative images of cortical neurons (DIV6) treated with compounds. See Figure S2 for the entire field of view from which these neurons were selected. (B) Sholl analysis demonstrates that 1-Me-DMT (27) and isoDMT (2) increase dendritic arbor complexity to a comparable extent as DMT (1) (n = 46–79 neurons). (C) Maximum number of crossings (Nmax) of the Sholl plots in B. Data are represented as mean ± SEM. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001, as compared to vehicle control following a one-way ANOVA with Dunnett’s post hoc test (F = 9.702; DFn = 4; DFd = 304; p-value < 0.0001). VEH = vehicle, KET = ketamine. Scale bar = 20 μm.