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. Author manuscript; available in PMC: 2021 Feb 13.
Published in final edited form as: J Med Chem. 2020 Jan 24;63(3):1142–1155. doi: 10.1021/acs.jmedchem.9b01404

Figure 6. Establishment of the essential psychoplastogen pharmacophore.

Figure 6.

(A) Chemical structures of non-basic analogs of of isoDMT 2. (B–C) Maximum number of crossings (Nmax) of the Sholl plots for cortical neurons treated with compounds (n = 46–85 neurons). The effects of nitrogen basicity and modifications to the aromatic ring were assessed in B and C, respectively. Data are represented as mean ± SEM. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001, as compared to vehicle control following a one-way ANOVA with Dunnett’s post hoc test (For B: F = 19.03; DFn = 4; DFd = 273; p-value < 0.0001. For C: F = 6.933; DFn = 8; DFd = 599; p-value < 0.0001). VEH = vehicle, KET = ketamine.