Summary of findings for the main comparison. Diaphragm‐triggered non‐invasive compared to other non‐invasive respiratory support for preventing respiratory failure in preterm infants.
| Diaphragm‐triggered non‐invasive compared to other non‐invasive respiratory support for preventing respiratory failure in preterm infants | ||||||
| Patient or population: preventing respiratory failure in preterm infants Setting: Intervention: diaphragm‐triggered non‐invasive Comparison: other non‐invasive respiratory support | ||||||
| Outcomes | Anticipated absolute effects* (95% CI) | Relative effect (95% CI) | № of participants (studies) | Certainty of the evidence (GRADE) | Comments | |
| Risk with other non‐invasive respiratory support | Risk with diaphragm‐triggered non‐invasive | |||||
| Failure of modality | Study population | RR 0.33 (0.02 to 7.14) | 16 (1 RCT) | ⊕⊝⊝⊝ VERY LOW 1 2 3 4 | ||
| 125 per 1000 | 41 per 1000 (3 to 893) | |||||
| Respiratory failure | Study population | ‐ | (0 studies) | ‐ | No study reported on this outcome | |
| see comment | see comment | |||||
| Chronic lung disease | Study population | ‐ | (0 studies) | ‐ | No study reported on this outcome | |
| see comment | see comment | |||||
| Mortality: prior to hospital discharge | Study population | ‐ | (0 studies) | ‐ | No study reported on this outcome | |
| see comment | see comment | |||||
| *The risk in the intervention group (and its 95% CI) is based on the assumed risk in the comparison group and the relative effect of the intervention (and its 95% CI). CI: Confidence interval; RR: Risk ratio; OR: Odds ratio | ||||||
| GRADE Working Group grades of evidence High certainty: we are very confident that the true effect lies close to that of the estimate of the effect Moderate certainty: we are moderately confident in the effect estimate: the true effect is likely to be close to the estimate of the effect, but there is a possibility that it is substantially different Low certainty: our confidence in the effect estimate is limited: the true effect may be substantially different from the estimate of the effect Very low certainty: we have very little confidence in the effect estimate: the true effect is likely to be substantially different from the estimate of effect | ||||||
1 Methodological concerns that lower confidence in the estimate of effect
2 Reported by single study only
3 Short time on respective interventions
4 Single reported event with CI including significant benefit and harm