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. Author manuscript; available in PMC: 2021 Apr 1.
Published in final edited form as: J Invest Dermatol. 2019 Sep 17;140(4):915–917.e2. doi: 10.1016/j.jid.2019.09.004

Fig 2. LTA mediated Basophil recruitment and IL-4 induction are suppressed by a blocking anti-TSLP mAb.

Fig 2.

(a) Mice were pre-treated with IP injection of isotype control or anti-TSLP mAb on days 0, 3 and 6. On day 6, mice were also injected ID with LTA. Skin samples at the injection site were harvested 48 hours post LTA treatment. (b) Increased epidermal thickness in skin treated ID with LTA. Tslp staining (red) is reduced by blocking anti-TSLP mAb in mice treated as described above. Bar = 80 mm. Dashed line represents epidermaldermal junction. (c) RT-PCR shows reduction in levels of Tslp, Mcpt8 (basophils) and Il-4 gene expression by treatment with Tslp blocking mAb. Data are mean ± SEM, n = 6, *P<0.05; **P<0.01.