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. 2019 Dec 13;14(2):102–108. doi: 10.4162/nrp.2020.14.2.102

Table 4. AUC(0-24 h) of isoflavone metabolites identified in the serum following Cheonggukjang ingestion according to Sasang typology.

No Metabolites SE SY TE P-value
1 Daidzein 56,399 ± 18,774.20a 29,480.4 ± 11,280.24a 748,491.8 ± 282,494.31b 0.000
2 Genistein 19,846.56 ± 8,312.65a 143,137.6 ± 67,995.08b 298,415.4 ± 116,138.76c 0.000
3 Glycitein 41,912.94 ± 11,314.79a 37,019.47 ± 7,346.46a 69,566.33 ± 23,136.25b 0.000
4 3-hydroxydaidzein 20,177 ± 8,951.96 7,286.25 ± 2,772.5 22,049.67 ± 30,174.84 0.349
5 2-hydroxygenistein 116,443.47 ± 108,650.35b 36,360.2 ± 12,293.57a 82,759.93 ± 63,820.57ab 0.020
6 Daidzein 4′-glucuronide 59,741.29 ± 17,786.70b 30,414.13 ± 7,265.75a 50,585 ± 14,090.84b 0.000
7 Daidzein 7-glucuronide 80,745.78 ± 29,501.35b 50,427.4 ± 11,690.16a 57,662.07 ± 24,969.74a 0.002
8 Daidzein diglucuronide 20,737.39 ± 6,555.99b 11,543 ± 4,877.33a 9,518.27 ± 3,777.76a 0.000
9 Daidzein 4′-sulfate 23,419.39 ± 7,387.22a 974,579.67 ± 340,431.08b 3,244,240.93 ± 1,063,972.11c 0.000
10 Daidzein 7-sulfate 4′-glucuronide 14,362.5 ± 8,030.20a 24,555.67 ± 6,302.61b 20,541.47 ± 9,702.07b 0.004
11 Genistein 7-glucuronide 64,426.39 ± 34,285.58 46,780.2 ± 21,151.31 43,054.73 ± 24,714.20 0.081
12 Genistein diglucuronide 82,762.56 ± 26,491.63b 34,285.87 ± 15,499.38a 34,636.87 ± 5,952.47a 0.000
13 Genistein-7-glucuronide-4′-sulfate 121,239.39 ± 88,332.07b 35,797.64 ± 27,104.94a 46,511.2 ± 13,365.33a 0.000
14 Genistein 4′-sulfate 78,567.89 ± 138,035.16 82,584.8 ± 21,945.13 - 0.000
15 Genistein-7-sulfate - - 243,616.87 ± 133,245.66 0.000
16 Dihydrogenistein 37,918.76 ± 34,160.86 85,911.36 ± 191,426.6 35,885.33 ± 25,312.26 0.404
17 Dihydrodaidzein sulfate 11,347.2 ± 7,347.72a 230,100.3 ± 139,539.94a 971,317.79 ± 640,145.02b 0.000
18 Equol-7-glucuronide 101,393.3 ± 67,588.67b 6,555.06 ± 3,139.22a 43,767.85 ± 62,165.99a 0.001
19 Equol-4-sulfate - - 35,441.67 ± 46,701.94 0.000
20 5-hydroxy equol 22,188.88 ± 31,641.4 8,758.6 ± 4,929.73 20,178.89 ± 17,117.64 0.593
21 O-Desmethylangolensin 33,917.38 ± 26,354.99b 13,765.62 ± 7,491.53a 30,201.8 ± 14,449.10b 0.019

SE, Soeumin; SY, Soyangin; TE, Taeeumin; AUC(0-24 h), area under the curve of the metabolite peak area versus time; -, cannot be calculated.

Differences among the groups were analyzed by Duncan's multiple range test (P < 0.05) and are indicated by different lowercase letters.

Letter “a” is significant to “b” and “c”, but “ab” is not significant.