Table 4. AUC(0-24 h) of isoflavone metabolites identified in the serum following Cheonggukjang ingestion according to Sasang typology.
No | Metabolites | SE | SY | TE | P-value |
---|---|---|---|---|---|
1 | Daidzein | 56,399 ± 18,774.20a | 29,480.4 ± 11,280.24a | 748,491.8 ± 282,494.31b | 0.000 |
2 | Genistein | 19,846.56 ± 8,312.65a | 143,137.6 ± 67,995.08b | 298,415.4 ± 116,138.76c | 0.000 |
3 | Glycitein | 41,912.94 ± 11,314.79a | 37,019.47 ± 7,346.46a | 69,566.33 ± 23,136.25b | 0.000 |
4 | 3-hydroxydaidzein | 20,177 ± 8,951.96 | 7,286.25 ± 2,772.5 | 22,049.67 ± 30,174.84 | 0.349 |
5 | 2-hydroxygenistein | 116,443.47 ± 108,650.35b | 36,360.2 ± 12,293.57a | 82,759.93 ± 63,820.57ab | 0.020 |
6 | Daidzein 4′-glucuronide | 59,741.29 ± 17,786.70b | 30,414.13 ± 7,265.75a | 50,585 ± 14,090.84b | 0.000 |
7 | Daidzein 7-glucuronide | 80,745.78 ± 29,501.35b | 50,427.4 ± 11,690.16a | 57,662.07 ± 24,969.74a | 0.002 |
8 | Daidzein diglucuronide | 20,737.39 ± 6,555.99b | 11,543 ± 4,877.33a | 9,518.27 ± 3,777.76a | 0.000 |
9 | Daidzein 4′-sulfate | 23,419.39 ± 7,387.22a | 974,579.67 ± 340,431.08b | 3,244,240.93 ± 1,063,972.11c | 0.000 |
10 | Daidzein 7-sulfate 4′-glucuronide | 14,362.5 ± 8,030.20a | 24,555.67 ± 6,302.61b | 20,541.47 ± 9,702.07b | 0.004 |
11 | Genistein 7-glucuronide | 64,426.39 ± 34,285.58 | 46,780.2 ± 21,151.31 | 43,054.73 ± 24,714.20 | 0.081 |
12 | Genistein diglucuronide | 82,762.56 ± 26,491.63b | 34,285.87 ± 15,499.38a | 34,636.87 ± 5,952.47a | 0.000 |
13 | Genistein-7-glucuronide-4′-sulfate | 121,239.39 ± 88,332.07b | 35,797.64 ± 27,104.94a | 46,511.2 ± 13,365.33a | 0.000 |
14 | Genistein 4′-sulfate | 78,567.89 ± 138,035.16 | 82,584.8 ± 21,945.13 | - | 0.000 |
15 | Genistein-7-sulfate | - | - | 243,616.87 ± 133,245.66 | 0.000 |
16 | Dihydrogenistein | 37,918.76 ± 34,160.86 | 85,911.36 ± 191,426.6 | 35,885.33 ± 25,312.26 | 0.404 |
17 | Dihydrodaidzein sulfate | 11,347.2 ± 7,347.72a | 230,100.3 ± 139,539.94a | 971,317.79 ± 640,145.02b | 0.000 |
18 | Equol-7-glucuronide | 101,393.3 ± 67,588.67b | 6,555.06 ± 3,139.22a | 43,767.85 ± 62,165.99a | 0.001 |
19 | Equol-4-sulfate | - | - | 35,441.67 ± 46,701.94 | 0.000 |
20 | 5-hydroxy equol | 22,188.88 ± 31,641.4 | 8,758.6 ± 4,929.73 | 20,178.89 ± 17,117.64 | 0.593 |
21 | O-Desmethylangolensin | 33,917.38 ± 26,354.99b | 13,765.62 ± 7,491.53a | 30,201.8 ± 14,449.10b | 0.019 |
SE, Soeumin; SY, Soyangin; TE, Taeeumin; AUC(0-24 h), area under the curve of the metabolite peak area versus time; -, cannot be calculated.
Differences among the groups were analyzed by Duncan's multiple range test (P < 0.05) and are indicated by different lowercase letters.
Letter “a” is significant to “b” and “c”, but “ab” is not significant.