Table 1.
Patient | WHO | Tumor de-differentiation | DOTATOC/-TATE | Activity PRRT (GBq) | PRRT Dose (Gy) | EBRT Dose (Gy) | Reduction in EBRT (Gy) | Clinical follow-up | Radiological follow-up (MRI) | PFS (mo) | OS (mo) | Follow-up (mo) | Progression | Death |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | 2 | 3 | DOTATOC | 6.98 | 4.0 | 60.0 | 0 | Loss of vision, pituitary insufficiency | PD | 26.2 | 38.2 | 38.2 | Yes | Yes |
2 | 1 | – | DOTATOC | 7.3 | 6.6 | 48.6 | 7 | No complaints | SD | 111.4 | 111.4 | 111.4 | No | No |
3 | n/a | – | DOTATOC | 7.49 | 4.0 | 50.4 | 4 | No changes | SD | 47.2 | 47.2 | 47.2 | No | Yes |
4 | 1 | – | DOTATOC | 7.2 | 0.2 | 54.0 | 0 | No changes | CR | 108.9 | 108.9 | 108.9 | No | No |
5 | 1 | – | DOTATOC | 7.6 | 6.7 | 54.0 | 0 | No changes | SD | 107.7 | 107.7 | 107.7 | No | No |
6 | 1 | – | DOTATOC | 7.9 | 22.3 | 41.8 | 11 | No complaints | SD | 108.7 | 108.7 | 108.7 | No | No |
7 | 1 | 2 | DOTATATE | 7.9 | 30.7 | 60.0 | 0 | Hemiparesis right | PD (03/17), then SD | 75.9 | 105.9 | 105.9 | Yes | No |
8 | 2 | 3 | DOTATATE | 7.2 | 7.2 | 40.0 | 0 | Multiple resections (WHO III), epilepsy | PD | 13.8 | 45.6 | 45.6 | Yes | Yes |
9 | n/a | n/a | DOTATATE | 7.3 | 16.6 | 54.0 | 0 | Parkinsońs disease | SD | 104.0 | 104.0 | 104 | No | No |
10 | 1 | – | DOTATATE | 7.4 | 8.2 | 52.2 | 6 | No changes | SD | 78.2 | 78.2 | 78.2 | No | No |
mo = months; n/a = not available.