Table 2.
Disease | Channels and Cells | Effects |
---|---|---|
Rheumatoid arthritis | Upregulation of CRAC on T cells Upregulation of TRPV1 and TRPM8 on synoviocytes Activation of TRPV4 on synoviocytes Activation of TRPV2 on synoviocytes |
Increase Ca2+ influx and NFAT transcription→ stimulation of secretion of inflammatory cytokines Activate caspase enzyme→ induce apoptosis of FLS Increase Ca2+ influx reduce→ chemokine production Increase intracellular Ca2+ concentration→ reduce joint inflammation |
Systemic lupus erythematosus | Altered motility of Kv1.3 on T cells | Activate T cell proliferation and T cell-mediated autoimmune responses |
Sjogren syndrome | Downregulation of CRAC on T regs Inhibition of TRPC3 on salivary gland |
Reduce SOCE and Treg functions→ decrease salivary gland secretion Reduce Ca2+ influx→ reduce cell-mediated toxicity→ decrease inflammation |
Psoriasis | Downregulation of TRPV6 on keratinocytes Downregulation of STIM1 |
Reduce Ca2+ influx→ inhibit keratinocyte differentiation and proliferation Reduce Ca2+ influx→ decrease chemotaxis of neutrophils |
Multiple sclerosis | Upregulation of CRAC on T cells | Change Ca2+ entry Stimulate T cell activation and proliferation→ increase cytokine production |
CRAC, Ca2+ release-activated Ca2+; NFAT, nuclear factor of activated T cell; TRPV, transient receptor potential vanilloid; TRPM, transient receptor potential melastatin; FLS, fibroblast-like synoviocyte; SOCE, store-operated Ca2+ entry; Tregs, regulatory T cells; TRPC, transient receptor potential canonical.