Figure 2.

Summary of pexophagy. (A) In macropexophagy, a form of macroautophagy selective for peroxisomes, a single membrane known as a phagophore engulfs a peroxisome for degradation. The phagophore matures into an autophagosome, which then fuses with a lysosome. Their fusion creates an autophagolysosome that degrades the target. (B) In mammalian systems, pexophagy occurs when Pex2 ubiquitinates Pex5. As a result, autophagy adaptor proteins NBR1 or SQSTM1 (p62) bind to ubiquitinated Pex5, and then eventually bind to LC3 on the phagophore. Due to this process, pexophagy occurs. Created using BioRender.