Table 1.

Baseline characteristics of include studies.

References	Region	Population	Diagnose of PA and EH	Treatment of PA	Follow-up	Events and incidence	Adjusted or balanced variables
Catena et al. (18)	Italy	54 consecutive patients (mean age: 53) who received a diagnosis of PA matched with 108 patients (mean age: 52) with EH	PA: increased plasma aldosterone–active renin ratio (≥20) EH: blood pressure 140/90 mmHg and/or current use of antihypertensive drugs	Unilateral adrenalectomy or spironolactone	7.4 years	PA: 0 (0%)	Matching: Age, sex, body mass index, duration of hypertension, systolic and diastolic blood pressure
						EH: 0 (0%)
Reincke et al. (19)	German	281 PA patients (mean age: 50) matched with 281 EH patients (mean age: 50)	PA: increased plasma aldosterone–active renin ratio (≥20) EH: blood pressure 140/90 mmHg and/or current use of antihypertensive drugs	Unilateral adrenalectomy (47%) or mineralocorticoid receptor antagonists	10 years	PA: 32 (11.39%) EH: 37 (13.17%)	Matching: Age, sex, BMI, systolic and diastolic blood pressure
					5 years	PA: 11 (3.91%) EH: 15 (5.34%)
					3 years	PA: 6 (2.14%)
						EH: 6 (2.14%)
Rossi et al. (23)	Italy	180 consecutive PA patients (mean age: 51.1) between 1992 and 2012, with 143 EH patients (mean age: 52.4) as controls; 148 of PA and 111 EH with followed data.	PA: standard guideline EH: No description	Unilateral adrenalectomy or mineralocorticoid receptor antagonists	3 years	PA: 1 (0.68%) EH: 1 (0.90%)	Crude
Chan et al. (20)	China	2,248 PA patients (mean age: 48.4) who ever used mineralocorticoid receptor antagonists, matched with 2,248 EH patients (mean age: 48.4)		Unilateral adrenalectomy or mineralocorticoid receptor antagonists	4.28 years	PA: 236 (10.50%) EH: 273 (12.14%)	Matching: Gender, age, baseline comorbidities, hypertensive drug, other concomitant medications
		875 APA patients (mean age: 46.62) matched with 875 EH patients (mean age: 46.31)	EH: blood pressure 140/90 mmHg and/or current use of antihypertensive drugs			APA: 28 (3.2%) EH: 84 (9.6%)
Hundemer et al. (21)	United States	602 PA patients (mean age: 58) matched with 41,853 age matched EH patients (mean age: 57). Patients of PA who underwent surgical adrenalectomy, had a previous cardiovascular event, were not treated with MR antagonists		All treated with mineralocorticoid receptor antagonists	10 years	PA: 131 (65.17%)	Matching: Age, previous cardiovascular event
						EH: 21,700 (51.85%)
					7.5 years	PA: 84 (22.39%)
			EH: medical records (ICD-9: 401.0, 401.1, 401.9; ICD-10: I10, I11, I12, I13)			EH: 14,463 (18.55%)
					5 years	PA: 45 (22.39%)
						EH: 7,763 (18.55%)
					2.5 years	PA: 19 (9.45%)
						EH: 1,737 (4.15%)
Rossi et al. (22)	Italy	41 APA patients (mean age: 50.9), 66 IPA patients (mean age: 49.6) and 894 EH patients (mean age: 46) for control	PA: increased plasma aldosterone–active renin ratio (≥40) at baseline and (≥30) postcaptopril administration	Unilateral adrenalectomy or mineralocorticoid receptor antagonists	12 years	PA: 66 (61.68%)	Balanced with gender, BMI, and Glomerular Filtration Rate (by baseline characteristics)
						EH: 595 (66.55%)
					9 years	PA: 12 (11.21%)
						EH: 152 (17.00%)
					6 years	PA: 1 (0.93%)
						EH: 15 (1.68%)
					3 years	PA: 1 (0.93%)
						EH: 7 (0.78%)
			EH: blood pressure 140/90 mmHg and/or current use of antihypertensive drugs		12 years	APA: 25 (60.98%)
						EH: 595 (66.55%)
					9 years	APA: 5 (12.20%)
						EH: 152 (17.00%)
					6 years	APA: 0 (0%)
						EH: 15 (1.68%)
					3 years	APA: 0 (0%)
						EH: 7 (0.78%)