Study findings suggest that patients with hypoparathyroidism experience a substantial burden of illness, both with respect to the range and severity of symptoms associated with the condition.

A validated disease-specific composite measure of symptoms in individual patients would be useful and help standardize the language used to describe the severity of the clinical syndrome in individual patients.

The validation-ready HPES-Symptom is intended to be a brief useful tool for assessing symptoms of hypoparathyroidism from the patient perspective, and for use in future studies that evaluate disease burden or treatment efficacy relating to symptom improvement among adults with hypoparathyroidism.