Fig. 3.

Horizontal boxplots showing the probability of occurrence of metastases for a pulmonary, breast, skin, genitourinary, gastrointestinal, and unknown primary (from top to bottom) for each of the five largest locations (a frontal; b cerebellum; c parietal; d temporal; e occipital). The vertical line in a–e represents the percentage of the respective lobe volume of the whole brain volume in the MNI space (or: the brain metastases probability that would statistically be expected in this region) with boxes to the right demonstrating a higher and boxes to the left a lower probability. The stars indicate statistical significance. The primary tumor groups “sarcoma” and “head and neck “ are not shown. GU genitourinary primary tumor, GI gastrointestinal primary tumor, CUP cancer of unknown primary