Table 1.
Distribution of the number of patients, number of BM, volume of single BM, age and gender per primary tumor entity
| Primary tumor | N patients/369 (%) | N BM/3313 (%) | N BM per patient | Single BM volume in cc | Age in years | Gender (n male (%)/n female (%) of 369 patients) |
|---|---|---|---|---|---|---|
| All patients | 369 (100) | 3313 (100) | 3 (1–6.5) | 0.08 (0.03–0.32) | 62 (54–71.5) | 184 (49.9)/185 (50.1) |
| Pulmonary | 167 (45.3) | 1619 (48.9) | 3 (1–6) | 0.07 (0.03–0.26) | 64 (55–72) | 89 (24.1)/78 (21.1) |
| NSCLC Adenocarcinoma | 118 (32.0) | 934 (28.2) | 3 (1–6) | 0.06 (0.02–0.25) | 63 (55–72) | 59 (16.0)/59 (16.0) |
|
NSCLC Large-cell carcinoma |
2 (0.5) | 11 (0.3) | 5.5 (2–) | 0.27 (0.07–1.77) | 63 (62–) | 0/2 (0.5) |
| SCLC | 46 (12.5) | 673 (20.3) | 3 (2–14) | 0.09 (0.03–0.27) | 67.5 (59.25–73.25) | 29 (7.9)/17 (4.6) |
| Unknown | 1 (0.3) | 1 (0.0) | 1 | 20.6 | 52 | 1 (0.3)/0 |
| Breast | 47 (12.7) | 669 (20.2) | 3 (1–11) | 0.01 (0.02–0.21) | 55 (46–69) | 3 (0.8)/44 (11.9) |
| Invasive ductal | 20 (5.4) | 315 (9.5) | 3.5 (2–9.5) | 0.03 (0.01–0.12) | 57 (46.25–70.5) | 2 (0.5)/18 (4.9) |
| Invasive lobular | 2 (0.5) | 18 (0.5) | 9 (2–) | 0.15 (0.09–0.44) | 64 (61–) | 0/2 (0.5) |
| Inflammatory | 2 (0.5) | 13 (0.4) | 6.5 (5–) | 0.44 (0.12–4.86) | 58.5 (47–) | 1 (0.3)/1 (0.3) |
| NST | 11 (3.0) | 223 (6.7) | 11 (2–36) | 0.06 (0.02–0.25) | 51 (46–69) | 0/11 (3.0) |
| Unknown | 12 (3.3) | 1 (0.0) | 1 (1–3) | 0.10 (0.04–0.49) | 57 (41.5–68) | 0/12 (3.3) |
| Skin | 45 (12.2) | 326 (9.8) | 2 (1–5) | 0.11 (0.03–0.56) | 65 (52–76) | 27 (7.3)/18 (4.9) |
| Melanoma | 43 (11.7) | 323 (9.7) | 2 (1–6) | 0.12 (0.03–0.57) | 65 (52–74) | 26 (7.0)/17 (4.6) |
| Merkel cell | 1 (0.3) | 2 (0.1) | 2 | 0.09 (0.02–) | 81 | 0/1 (0.3) |
| Squamous cell carcinoma | 1 (0.3) | 1 (0.0) | 1 | 0.01 | 89 | 1 (0.3)/0 |
| GU | 45 (12.2) | 348 (10.5) | 3 (1–5) | 0.10 (0.03–0.40) | 61 (55–73) | 26 (7.0)/19 (5.1) |
| Kidney | 17 (4.6) | 62 (1.9) | 3 (1–5.5) | 0.12 (0.05–1.68) | 63 (56.5–75) | 7 (1.9)/10 (2.7) |
| Prostate | 10 (2.7) | 95 (2.9) | 3 (2–5.5) | 0.02 (0.01–0.05) | 65 (60.75–73.75) | 10 (2.7)/0 |
| Urothelial cell | 6 (1.6) | 74 (2.2) | 9.5 (2.5–22.75) | 0.25 (0.09–0.63) | 62 (52–69.25) | 4 (1.1)/2 (0.5) |
| Ovarian | 5 (1.4) | 9 (0.3) | 5 (1–3) | 0.78 (0.02–5.53) | 59 (53–71) | 0/5 (1.4) |
| Testicular | 5 (1.4) | 106 (3.2) | 5 (1.5–49) | 0.13 (0.03–0.27) | 35 (27–40.5) | 5 (1.4)/0 |
| Uterine | 2 (0.5) | 2 (0.1) | 1 | 2.3 (2.01–) | 51.5 (45–) | 0/2 (0.5) |
| GI | 36 (9.8) | 175 (5.3) | 2 (1–5.5) | 0.09 (0.04–0.53) | 59 (54.25–67) | 20 (5.4)/16 (4.3) |
| Colon | 12 (3.3) | 81 (2.4) | 2.5 (1.25–6) | 0.07 (0.03–0.29) | 54.5 (49.25–58.75) | 5 (1.4)/7 (1.9) |
| Rectal | 8 (2.2) | 24 (0.7) | 2 (1–6) | 0.15 (0.03–14.14) | 58.5 (47–66.75) | 4 (1.1)/4 (1.1) |
| Esophageal | 7 (1.9) | 21 (0.6) | 1 (1–2) | 0.08 (0.04–2.14) | 68 (58–71) | 6 (1.6)/1 (0.3) |
| Gastroesophageal | 4 (1.1) | 27 (0.8) | 4 (3.25–13) | 0.18 (0.06–1.01) | 61.5 (57.75–69.75) | 3 (0.8)/1 (0.3) |
| Gastric | 1 (0.3) | 2 (0.1) | 2 | 3.22 (2.04–) | 66 | 0/1 (0.3) |
| Neuroendocrine | 1 (0.3) | 16 (0.5) | 16 | 0.13 (0.05–0.21) | 62 | 1 (0.3)/0 |
| Duodenal | 1 (0.3) | 2 (0.1) | 2 | 21.26 (0.28–) | 56 | 1 (0.3)/0 |
| Gallbladder | 1 (0.3) | 1 (0.0) | 1 | 0.30 | 59 | 0/1 (0.3) |
| Cholangiocellular | 1 (0.3) | 1 (0.0) | 1 | 8.05 | 70 | 0/1 (0.3) |
| CUP | 18 (4.9) | 130 (3.9) | 1 (1–11.25) | 0.13 (0.05–0.68) | 62 (56–75.25) | 11 (3.0)/7 (1.9) |
| Sarcoma | 9 (2.4) | 42 (1.3) | 3 (1–6.5) | 0.53 (0.16–6.10) | 48 (34.5–65.5) | 7 (1.9)/2 (0.5) |
| Liposarcoma | 2 (0.5) | 8 (0.2) | 4 (1–) | 0.81 (0.08–20.17) | 71.5 (67–) | 1 (0.3)/1 (0.3) |
| Angiosarcoma | 1 (0.3) | 3 (0.1) | 3 | 8.9 (6.6–) | 47 | 1 (0.3)/0 |
| Ewing sarcoma | 1 (0.3) | 1 (0.0) | 1 | 5.93 | 30 | 1 (0.3)/0 |
| DSRCT | 1 (0.3) | 19 (0.6) | 19 | 0.46 (0.21–0.89) | 39 | 1 (0.3)/0 |
| Soft tissue sarcoma | 1 (0.3) | 1 (0.0) | 1 | 13.67 | 64 | 1 (0.3)/0 |
| Synovial sarcoma | 1 (0.3) | 6 (0.2) | 6 | 0.05 (0.02–9.58) | 28 | 1 (0.3)/0 |
| Endometrial stromal sarcoma | 1 (0.3) | 1 (0.0) | 1 | 36.98 | 56 | 0/1 (0.3) |
| Unknown | 1 (0.3) | 3 (0.1) | 3 | 12.57 (0.01–) | 48 | 1 (0.3)/0 |
| Head/Neck | 2 (0.5) | 4 (0.1) | 2 | 6.74 (0.13–35.10) | 64 (58−) | 1 (0.3)/1 (0.3) |
| Tonsillar | 1 (0.3) | 2 (0.1) | 2 | 27.8 (13.3–) | 58 | 1 (0.3)/0 |
| Thyreoid | 1 (0.3) | 2 (0.1) | 2 | 0.14 (0.12–) | 70 | 0/1 (0.3) |
BM brain metastasis, cc cubic centimeter, CUP cancer of unknown primary, DSRCT desmoplastic small round cell tumor, GI gastrointestinal primary tumor, GU genitourinary primary tumor, N number of, NST invasive carcinoma of no special type