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. 2020 Mar 10;11:383. doi: 10.3389/fimmu.2020.00383

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Copyright © 2020 Renaud, da Silveira, Takamura, Hardiman and Feghali-Bostwick.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Similarity matrix. The raw data for all 425 DE genes (common and unique to both diseases) was uploaded to MORPHEUS to generate a similarity matrix. Three main clusters are apparent, cluster-1 made up of NL samples only, cluster-2 and cluster-3 made up of SSc-PF and IPF samples intertwined, emphasizing that the gene signatures of these 2 diseases are very similar.